ESOMPERAZOLE AND DOMPERIDONE

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  Esomperazole and Domperidone   -  This combination is used to reduce or inhibit acid secretion from stomach. This medicine is given with many other tablets.  Working mechanism - here the drug esomperazole is proton pump inhibitor which reduce acid secretion and Domperidone is antagonist to dopamine , reduce feeling of nausea, vomiting etc. This medicine is given to neutralize or reduce acidity of stomach such that another medicine given which works in less acidic medium can work efficienctly.  Uses -   . Mostly given with many antibiotics.                . Given with many other medicine.                 . Reduce nausea and vomiting feeling due to medicine.                  . Use to reduce acidity such that given medicine can work efficienctly.   Dose - given usually during ones a day with empty stomach or befor...

ASPIRIN - USES, SAFE DOSAGE, SIDE EFFECTS, ETC.

 ASPIRIN - Non steroidal anti inflammatory drug ( NSAID)



  ANALGESIC ( pain killer) ,                   ANTIPYRETIC( reduce temperature) , ANTI INFLAMMATORY. 

Working mechanism - inhibit production of prostaglandin by effecting enzyme involved in process. 

   USES - Headache, backache, joint pain,      toothache, Dysmenorrhea. 

Aspirin 75 mg given to cardiac patients to reduce chances of myocardial infraction after surgery or as per requirement. 

 SAFE DOSAGE - As ANALGESIC - given in low dose 0.3 - 1.5 mg / day Or 0.3 - 0.6 mg in 6 - 8 hr. 

Maximum ANALGESIC effect at 1000 mg. 

- As  INFLAMMATORY - given in high dose 3 - 6 g / day 

BRAND - ASPIRIN 350 mg tablet 

                ECOSPRIN 75 , 150, 325 mg 

                DISPRIN 350 mg 

                 COLSPRIN 100 - 325 mg 

In high dose available as injectables - BiOSPRIN ( lysin acetylsalicylate 900mg + glycine 100 mg given by dissolving in 5 ml water ) 



SIDE EFFECTS -  . Damage Gastric mucosa and produce peptic ulcer . 

                               . Common symptoms like nausea ,vomiting and epigastric distress. 

                               . Aspirin in children with rheumatoid arithritis can cause liver damage . 

                               . Not recommended to diabetes patients. 

                               . Unavailable for pediatric  solution ( children treatment) suffering from chicken pox, influenza. 

  Key point - not recommended for pregnant and lactating women without concerning Doctor. 

As if given to pregnant women frequently results in baby with low weight. 

In Case of  fever 🤒 mostly paracetamol is recommended over aspirin. 

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